Luderer U, Eskenazi B, Hauser R, Korach KS, McHale CM, Moran F, Rieswijk L, Solomon G, Udagawa O, Zhang L, Zlatnik M, Zeise L, Smith MT. 2019. Key Characteristics of Female Reproductive Toxicants as an Approach for Organizing and Evaluating Mechanistic Data in Hazard Assessment. Environmental Health Perspectives. 127(7). DOI: 10.1289//EHP4971
We applied a key characteristics approach originally developed for carcinogens to female reproductive hazard identification. We identified 10 key characteristics of female reproductive toxicants. As proof of principle, we showed that three chemicals for which there is strong epidemiological and animal toxicology evidence for female reproductive toxicity each display several of the key characteristics. We propose that these key characteristics can be used to systematically search, organize, integrate, and evaluate mechanistic evidence of female reproductive toxicity.